BIOL 1F25 Lecture Notes - Cell Surface Receptor, Activin And Inhibin, Neural Crest
30 Jan 2013
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Document Summary
Cell-cell interactions determine decisions to apoptose, differentiate, migrate, and. First observed by spemann and mangold in 1920 s. Induction is when an inducing tissue causes a competent responding tissue to alter its differentiation. Induction is widespread and is a key way of controlling embryonic development. There are two types of induction: instructive: specific inducing signal required for response, usually early, permissive: nonspecific signal can produce progression to final differentiated state, usually later dev. Mesoderm induction in xenopus can be investigated with an in vitro assay. Activin is a potent mesoderm inducer, but probably is not the endogenous one. Vg-1 may be the endogenous mesoderm inducer. In mammals, nodal may be the mesoderm inducer can induce mesoderm. White and steel mice have different mutations but same phenotype. The underlying phenotype is dysfunction in tissues that require cell migration (e. g. neural crest cells, hematopoietic cells, germ cells) during development.
