BIOC33H3 Lecture Notes - Neutrophil, Wound Healing, Leukocyte Extravasation
25 Mar 2013
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Document Summary
The inflammatory response is a sequential reaction to cell injury. It neutralizes and dilutes the inflammatory agent, removes necrotic materials, and establishes an environment suitable for healing and repair. The basic types of inflammation are acute, subacute, and chronic. In acute inflammation, the healing occurs in 2 to 3 weeks and usually leaves no residual damage: subacute inflammation has the features of the acute process but lasts longer, chronic inflammation lasts for weeks, months, or even years. The inflammatory response can be divided into a vascular response, a cellular response, formation of exudate, and healing. The vascular response results in vasodilation causing hyperemia (increased blood flow in the area), which raises filtration pressure. During the cellular response, neutrophils and monocytes move to the inner surface of the capillaries (margination) and then through the capillary wall (diapedesis) to the site of injury. Exudate consists of fluid and leukocytes that move from the circulation to the site of injury.
