Microbiology and Immunology 3300B Study Guide - Final Guide: Central Tolerance, Peripheral Tolerance, Afferent Arterioles
29 Mar 2013
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Hematopoesis, antibody rearrangement, central tolerence (rendered self reactive or not) Bony trabeculae where immune cells develop, spaces between is where hematopoeisis occurs and also adipocytes are also present there. Bell cells go through apoptosis or they undergo change to make them inactive. If good they stay as receptors: describe central tolerance in the thymus. Start with the tcr genes rearranging within the cortical epithelial region, then being selected negatively against within the medulary epithelial region, no idea what occurs in the hassels corpus region: discuss the thymus mutation. Corticol sinus seperates the components of the lymph node. B cells are found in the primary lymphoid follicle, t cells are found in the paracortical area. Antigens will perculate down the cortical sinus as the structure changes with immune response. B/t cells will wait and then divide when active. Germinal centre stores b cells for future attack. T and b cells interact in the if zone.
