NURS 2050 Lecture Notes - Diuretic, Water–Electrolyte Imbalance, Spironolactone
11 Apr 2013
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Diuretics: prevent resorption of nacl (and blocking passive resorption of water, by increasing osm) Can give large doses, without reaching a peak. Good in those with renal impairment (don"t need. Not for those with renal impairment (need gfr), or for those allergic to sulfonamides. This one prevents resorption of nacl, but also resorbs k. Aldosterone reabsorbs water and na, but excretes k. with this diuretic, potassium is spared. Used with htn and severe heart failure. Adverse reactions: k, na, endocrine effects (b/c of steroid like structure, gynecomastia, altered menses) Adverse reactions for all: hypovolemia, electrolyte imbalance, acid-base imbalance. Spironolactone will spare k and promote renal resorption of k to block aldosterone. Stop conversion of ang i ang ii. Uses: htn, reduces mortality in ppl with mi. ** ci for bilateral renal stenosis b/c they are excreted by kidneys, so it reaches toxic levels. Has similar side effects, minus the bradykinin cough.
