PHAR 100 Lecture Notes - Flumazenil, Nonsteroidal Anti-Inflammatory Drug, Phenytoin

• School: Queen's University
• Department: Pharmacology and Toxicology
• Course: PHAR 100
• Professor: Hisham Elbatarny

Document Summary

Drug toxicity and routes of administration: drug toxicity, (acute [usually one large dose] and chronic [occurs from long-term use ~3mnths) Caution: almost all drugs have adverse effects, dose, individual - may be genetic, age; ex: newborn should not be treated like a small adult, disease state; ex: live cirrhosis (most drugs metabalized by liver, categorize adverse effects. What michael jackson was administered on june 25th 2009. Michael jackson was given a series of sedatives by dr. conrad murray on june 25, the day the singer died, according to an affidavit released yesterday (august 24, 2009) in houston. 1:30 am: 10 mg tablet of diazepam (valium) 10:40 am: 25mg of propofol (general anaesthetic never used outside of medical facility or outside of hands of anaesthetist) given iv and diluted with lidocaine. 10:50 am: doctor leaves jackson"s room; returns minutes later to find jackson not breathing: begins cpr and gives 0. 2mg flumazenil iv.