Microbiology and Immunology 3300B Lecture Notes - Pattern Recognition Receptor, Pathogen-Associated Molecular Pattern, Ubiquitin Ligase
12 Dec 2013
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Document Summary
Individual pamps will be present on a broad range of pathogens. A lot of the pamps that we detect are found in the cell wall. Human dna methylation of cytosines: bacteria dna differs as their cytosines are not methylated. Cpg dna dna bases are held together by phosphodiester bonds which is what the p stands for. Flagellin highly conserved evolutionarily, and thus act as pamps. Viruses have pamps associated with them as well. Some viruses are double stranded rna, are interpreted as foreign as our rna is mostly single-stranded. Gain entry into our cells through the endosomal pathway, but our dna is in the nucleus and rna is in the nucleus/cytoplasm so our bodies detect dna found in the endosomal pathway as something foreign. 2 major types: toll-like receptors (tlrs, non-tlrs. Investigation showed that fungus had grown inside the fly: flies do not have adaptive immune systems, innate immune system only.
