BIOL 314 Lecture Notes - Gene Silencing, Euchromatin, Sox2
27 Feb 2014
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Document Summary
An abnormal cell growth within a given tissue. Tumors arise from normal tissues: ectoderm (neural & non-neural), mesoderm or. Epithelial-mesenchymal transition or transformation (emt) is a process by which epithelial cells lose their cell polarity and cell-cell adhesion, and gain migratory and invasive properties to become mesenchymal cells. Basement membrane not breached, localized growth exclusively, best prognosis! Proliferation in situ, invasion of adjacent structures: (basement membrane, then stroma. ) Ability to move and disseminate at a distance: metastasis. Creation of its own vascular network: neoangiogenesis. The process by which a less specialized cell becomes a more specialized cell type. Ability to move and disseminate at a distance. Metastasis is an inefficient process, metastasis is often specific to certain areas depending on the original cell. Initially localized to a cell layer, disseminate locally, regionally then at a distance. Early detection can be very important for prevention. Extensive data on molecular aspects: tumoral genome, tumoral transcriptome, signaling pathways.
