Pathology 3240A Lecture Notes - Apoptosis, Thrombocytopenia, Immunoglobulin A
3 Mar 2014
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B cells recognizing self antigen may undergo apoptosis or receptor: change antigen receptor so that it doesn"t no longer, peripheral tolerance inactivation or deletion of self reactive t cells in the recognizes self peripheral blood/tissues (ie. outside the thymus) 1/700 inchild bearing ag: failure of self soleracne, results in production of autoantibodies antinuclear antibodies anti dna, histones, nucleolar antigens antibodies against blood cells antiphopholipid antibodies, immune complex formation (types iii hypersensitivity) results in organ and skin damage immune complex deposition and complement activayion, opsonisation and phagocytosis (type ii hypersensitivity) also plays role, especiallywith antibodies against blood cells anemia, thrombocytopenia, major manifestations skin manifestations (molar rash uv light and inflammation) kidney manifestations (lupus nephritis) joint disease (swelling) Immunodeficiency classification primary: inherited defects of immune system secondary, deficiency of immune function secondary to another disease process infection immunosuppression aging. Malnutrition primary immuno: after components of either: innate imunity phagocytes, nk cells, complement proteins.
