SOCR 330 Lecture Notes - S Phase, Apoptosis, Continuous Signal
Document Summary
Migration of malignant cell to other sites (metastasis) Tumors derived from repeated division of an individual transformed cell. Limited lifespan in culture (lose telomeres and stop dividing) Need to attach to hard surface in culture. Genetically unstable (high rates of mutation and aneuploidy) Malignant cells result of mutation in key genes. Cancer may result from multiple mutations (e. g. colon cancer) or a single mutation (e. g. Cancer may result from multiple mutations (e. g. colon cancer) or a single mutation (e. g. retinoblastoma) Binds to e2f transcription factor preventing g1/s transition in cell cycle. E2f initiates transcription in other genes moving cell cycle to s phase. Mutant rb alleles found in retinoblastomas and osteosarcomas fail to produce prb. Inactivating tumor suppressor genes: p53 gene p53 protein involved in. Expression of > 20 other genes targeted by p53 protein. 50 60% of all human cancers have p53 mutation. Individuals heterozygous for p53 mutation have 90 95% probability of developing cancer.
