LMP299Y1 Lecture Notes - Lecture 6: Histocompatibility, Aspirin, Nocturia

• School: UTSG
• Department: Laboratory Medicine and Pathobiology
• Course: LMP299Y1
• Professor: Kenneth Yip

Document Summary

Kidney: elimination of waste. Normal creatinine (depends on body size and living style) Renal function unit of the kidney: nephron. 1000s of nephrons in the kidney it"s the functional unit of the kidney. ~1200ml/min of blood: ~120ml/min of filtrate produced. = glomerular filtration rate (gfr) Gfr measures kidney function. Gfr can be measured by estimating the creatinine clearance based on creatinine in plasma and a 24h urine (collect. Gfr is inversely proportional to plasma creatinine. Gfr may be roughly estimated by the inverse of plasma creatinine: gfr 1/[pcr] Acute renal failure acute renal failure changes happen rapidly and are usually reversible. Can be treated if you restore the fluid balance in time. Arf has rapid onset in the course of hours or days. Reversible if fluid balance is restored in time. Early detection relies on sequential monitoring of renal function tests (urea and creatinine) Urea and creatinine would rise quickly.