BIOC34H3 Lecture Notes - Lecture 17: Renal Function, Macula Densa, Internal Sphincter Muscle Of Urethra

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20 Apr 2014
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Lecture 17: glomerular filtration, tubular absorption, tubular secretion, excretion, Micturition and ion balance: regulation of glomerular filtration rate. Myogenic regulation of glomerular filtration rate (gfr) occurs via vascular smooth muscle found around the afferent glomerular arteriole. This is stretch-sensitive smooth muscle which, in response to an increase in blood pressure, will contract and reduce the diameter of the afferent arteriole (vasoconstriction). This increases the resistance to flow and therefore decreases blood flow which in turn decreases glomerular hydrostatic pressure and therefore gfr does not increase. Thus, even though mean arterial pressure increases gfr is kept constant. Vasoconstrictor substances are released in response to an increase in filtrate flow through the distal tubule, and a. 2 corresponding increase in sodium and chloride content of the fluid surrounding the cells of the macula densa. Vasoconstrictor substances are released in order to counter an increase in filtration while vasodilator substances will counter a decrease in filtration.

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