MIP 342 Lecture Notes - Antigen, List Of North American Broadcast Station Classes, Germinal Center
11 Jul 2014
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Document Summary
Early lymphoid progenitor (etp) enters the thymus at the cortico-medullary junction. Not committed to t cell lineage yet (if picked up and put in bone marrow, could become b cell, nk cell) Notch-1 receptor on the early lymphoid progenitor receives signal (notch protein) from thymic stroma to commit to the t cell lineage. A successfully produced -chain protein binds to a surrogate -chain. The newly formed pretcr associates with cd3 at the surface. Now, the pretcr can send a signal that halts -chain rearrangement so the other -chain allele shouldn"t get made (allelic exclusion) Also sends a signal to move to the next step. When proliferation stops, the immature t cell expresses cd4 and cd8 at the surface and -chain gene rearrangement begins. Dp t cells interact with thymic cortical epithelial cells in the cortex. Dp t cells that can recognize self mhc (and self ag) will survive and drop either cd4 or.
