MIP 342 Lecture Notes - Mhc Class Ii, Transporter Associated With Antigen Processing, Somatic Hypermutation
Document Summary
Cd4 (helper t cells) binds to mhc class ii. V-region assembly somatic recombination of dna, irreversible change, occurs in b and t cells. Junctional diversity imprecise joining, n-sequence insertion in dna, irreversible change, occurs in b and t cells. Switch recombination (class switching) somatic recombination of dna, irreversible change, occurs in b cells. Somatic hypermutation dna point mutation, irreversible change, occurs in b cells. Igm, igd expression on surface differential splicing of rna, reversible and regulated change, occurs in b cells. Membrane vs. secreted forms differential splicing of rna, reversible and regulated change, occurs in b cells. Exogenous antigens outside, phagocytosed and shown to cd4. Effect on presenting cell activation to kill intravesicular bacteria and. Effect on presenting cell activation of b cells to secrete ig to eliminate extracellular bacteria/toxins. Uptake mechanisms direct antigen into intracellular vesicles for exogenous antigen processing. Chaperones proteins that assist in folding/assembly of other proteins.