IMM250H1 Lecture : Notes taken during lecture
Document Summary
Hsc also gives rise to platelets and rbcs. Hsc doesn"t become end cell stages immediately but through developmental check points. Microenvironment of bone marrow, including cell to cell contact and cytokines as mediators and regulators of growth and differnetiaiton of h precusors. Clinical importance ability through bone marrow transfers to provide reconstitution of cell populations and ultimately, the potential uses of stemm cell therapy and gene therapy. Wide range of h tissues and tissues of immune system all around body. Broadly categorized into two types of tissues . Primary or central lympohid organs bone marrow in bones of body; thymus essential for generation of t lymphocytes; bone marrow source of progentiors of all h cells and bone marrow is site where b lymphocytes undergo development. T and bone marrow are primary lympohid organs because where cells of immune system develop; not where immune responses take place.
