Anatomy and Cell Biology 4429A Lecture : Protein Folding Diseases
22 Dec 2011
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In the er, it is made with three carbohydrate chains. As we take it our of the er and send it to the protesome, the protein inhibits the protesomal degradation pathway and it could start to aggregate. As cells grow old they must be replaced. Over a lifetime, the liver now becomes challenged and goes through unnecessary rounds of mitosis. Have a bunch of proteins taken up and targeted to the lysosome but we couldn"t get rid of them and didn"t know why. In the golgi, we have the cis, medial and trans golgi. The mannose-p targets the protein to the lysosome. The reason for this is when some of these vesicles bud off of the trans golgi, a different pathway will take them to the plasma membrane. If you"re not wearing a baggage tag, you"re heading for secretion out of the plasma membrane. The absence of this means that this molecule cannot have the targeting signal on it.
