IMM250H1 Lecture : Lecture notes
Document Summary
I to iii chimera questions similar questions go to these tutorials 25/40 questions of tt2. Used coated plate assay put anti-tcr on plate focusing on cd4 combination of two did induce the t cells. Use beads tcr beads, beads caoted with anti-tcr with beads coated with beads contained mixture of anti-tcr and cd4 resolved coaggregation of cd4, and cd8. Cd28 and its ligand found to be critical cd28 expressed on most t cells ligand for cd28. B cells that are not activated are small, high buoyant density, resting cells. Activated b cells become larger, express b7 molecules. Lots of cell made in thymu go through negative selection remove cells that recognize self mhc with high affinity. Some cells escape negative selection, go to periphery, cn do harm role of professional apc here: if eventually a t cell recognizes antigen in context of mhc on a non-professional apc, ie. b7 not expressed.
