CSB331H1 Lecture Notes - Lecture 15: Thrombospondin, Bone Morphogenetic Protein 7, Neural Plate
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Lecture 15 march 14, 2011 (1) somitogenesis and intersomitic boundary formation |eph-ephrin signaling (2) neural crest cell migration. Notes from gilbert (2003) developmental biology, 7th ed. Pasquale (2005) eph receptor signaling casts a wide net on cell behavior. 6:462 a subset of the text is verbatim. Commitment: signaling events that result in the commitment of a cell towards a particular cell fate. Commitment can be subdivided into two stages: specification and determination: specification: the first stage of commitment. The key point is that while its fate has become more restricted, its fate can be reversed by placing the cell in a new environment, i. e. position in an early embryo: determination: the second stage of commitment. A cell is said to be determined when its fate cannot be altered by placing it in another region of an embryo. Hence, it differentiates according to its original fate in the embryo.