BIOL201 Lecture Notes - Lecture 11: Tradd, Tnf Receptor Superfamily, Caspase 8
15 Apr 2012
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We have been discussing how cells can divide and how that division can be controlled. However, the pathways controlling where and when a cell dies are critical to maintaining the health of an organism. Apoptosis, or programmed cell death, is a major cellular pathway that is highly controlled by both intra- and extracellular signals. Biology 201: characteristics (page 592, figure 19-44) Biology 201: signals controlling apoptosis (page 593-594) The continued survival of most cells requires that they receive continuous stimulation from other cells and, for many, continued adhesion to the surface on which they are growing. There are 3 different mechanisms by which a cell commits suicide by apoptosis. Caspases - a family of over a dozen caspases. They get their name because they cleave proteins mostly each other at aspartic acid (asp) residues). Dr. torah kachur: apoptosis triggered by internal signals: the intrinsic or mitochondrial pathway (cid:120)
