CHEM 183 Lecture Notes - Salicylic Acid, Salicin, Antipyretic

• School: McGill University
• Department: Chemistry
• Course: CHEM 183
• Professor: David Harpp

Document Summary

Chemistry of drugs lecture 2: pain relievers (analgesics) ~ billion on otc drugs: highest: cough and cold, followed by: pain relievers, antacids, oral antiseptic, laxatives. Safety of otc: indications and counter indications, side-effects. Most widely-used worldwide is aspirin: 50 billion tablets/year worldwide. Salix (salicylates) family: willow tree, poplar, beech, wintergreen: willow leaves used in 2,200 bc for joint pain by sumerians (wound inflammation) Reverend edward stone, 1763 ague with 20 grains of powdered willow bark in dram of water every 4 hours to cure people: willow trees grow in marshes. Stone thought there was something beneficial in trees that allowed them to grow in the water. Cinchona tree bark for malaria: side effect: bitter, stomach irritation. Willow bark (1829) salicin (1838) salicylic acid anti-inflammatory,