PHGY 210 Lecture : PHGY210- Lecture 38- Dr. Takano.docx
Document Summary
Responses to acidosis (high h+ concentration: sufficient h+ are secreted to reabsorb all the filtered hco3, still more h+ are secreted and this contributes new hco3 these h+ are excreted bound to non-hco3. 2-: tubular glutamine metabolism and ammonium excretion are enhanced, which also contributes new hco3. Than usual are added to the plasma, thereby compensating for the acidosis. The urine is highly acidic (lowest attainable ph = 4. 4). Responses to alkalosis (low h+ concentration: rate of h+ secretion is inadequate to reabsorb all the filtered hco3. , so the significant amounts of hco3: there is little or no h+ secretion on non-hco3. Urinary buffers: tubular glutamine metabolism and ammonium excretion are decreased, so that little or no new hco3. Is contributed to the plasma from this source. Will decrease, thereby compensating for the alkalosis. The urine is highly alkaline (ph > 7. 4).