BIO230H1 Study Guide - Final Guide: Netrin, Cell Division, Death Effector Domain
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BIO230H1 Full Course Notes
Verified Note
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Document Summary
Membrane trafficking is important for cells to: communicate with other cells, acquire resources. Involve polarized trafficking routes vesicles have origins and destinations, go both ways: presence of sorting stations e. g. , tgn to endosome and plasma membrane, retrieval mechanism and general balance among routes. Keeps on secreting: soluble proteins, plasma membrane lipids and proteins: regulated secretory pathway. Endocytosis: endocytosed vesicle joins early endosome, routes to various destinations. Recycling moves back to original domain. Transcytosis moves to opposite domain (apical or basolateral) Degradation moves to lysosome: collect resources. E. g. , ldl uptake ldl receptors endocytosis uncoating fusion with endosome separation of ldl from receptor fuse with lysosome: down regulate cell surface signalling. Unwanted receptors tagged by ubiquitin endocytosis forms multivesicular body degraded by lysosomal protease and lipase. Pseudopods extend out and grab substances - engulf targets. Local membrane changes: fusion snares (v and t snares, forms helices, excludes water, hemifusion- fusion)
