Match the following design control terms to their definition below: design history file, design validation, design verification, document control.

A mechanism for managing changes to a product’s design

Confirms that the product meets the specifications laid out by the product development team

The complete collection of documentation for a finished medical device

Confirms that the design specifications meet customer requirements

a. Design history file

b. Design validation

c. Document control

d. Design verification

Which of the following statements is true

[A] Evolution by natural selection "works" like an engineer, free to develop different designs.

[B] Nearly all evolutionary innovations are the result of modifications of previously existing mechanisms and structures.

[C] The genes that control development are highly conserved.

[D] Both a and b

[E] Both b and c

1. One of the first stages of drug design is the identification of a compound (a lead compound) that interacts the target of interest. This active compound is then further modified in the drug development process. Briefly describe how the following can be sources of these active compounds:

Natural products

Chemical (compound) libraries

Existing drugs

2. Describe what is meant by the following two approaches in computer-aided drug design.

Ligand-based drug design

Structure-based drug design

1. Cellular morphology contributes to the morphogenesis of the organism. Describe an experiment which demonstrates that the nucleus controls cell morphology. Include the hypothesis, the experimental organisms, the experimental design, results and conclusions and interpretation.

2. Cellular morphology contributes to the morphogenesis of the organism. Describe an experiment which demonstrates that cytoplasmic factors control cell morphology. Include the hypothesis, the experimental organisms, the experimental design, results and conclusions.

3. Give three examples of how the environment can change development and sends crucial signals for an organisms development.

4. Compare and contrast mosaic and regulative development. Define autonomous specification and give an experimental example of autonomous development. Be sure to include the hypothesis, the experimental organisms, the experimental design, results and conclusions.