A gene has the following DNA sequence: ATTATTCG

A mutation occurs that replaces cytosine with thymine. What mRNA sequence corresponds to the new, mutated, DNA sequence?

a TAATAAGC b AUUAUUUG c TAATAAAC d UAAUAAAC

Gene A has the following DNA sequence:
5

6. A point mutation replaces the third base with guanine in the following DNA sequence: AGCTTGTTAACCGTAGGT . You may use an online genetic code table.

What will happen to the amino acid sequence that is formed based on the mutated DNA sequence?

a) The first amino acid will change from asparagine to serine

b) The first mRNA codon will change from serine to asparagine

c) All the amino acids will change

d) All amino acids will remain the same

e) The first amino acid will change from serine to tryptophan

Assume that the following is the entire sequence of a shortprotein which did not require mRNA splicing prior to itstranslation: NH2-Met-His-Leu-Tyr-Ile-His-Cys-Trp-Gln-Lys-Phe-COOH

a. Write out the sequence of a possible mRNA molecule encodingthis protein. You do not need to write out 5’-UTR or 3’-UTRsequences. Be sure to label 5’ / 3’ directionality.

b. Write out the sequences of both strands of thedouble-stranded DNA molecule corresponding to the mRNA and protein.You only need to write the portion of the double-stranded DNAmolecule which corresponds to the mRNA sequence in part (a). Labelthe template and non-template strands as well as 5’ / 3’directionality.

c. Identify three bases in the DNA molecule, each of which, ifmutated, will result in a nonsense mutation. Above each of thesenucleotides, write the base which will result in a nonsensemutation.