ANSC 234 Study Guide - Midterm Guide: Lipoprotein, Phosphoenolpyruvic Acid, Triosephosphate Isomerase

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Complementarity: 2 structures each following the lock-and-key mechanism both the enzyme and substrate possess speci c complementary geometric shapes that t exactly into one another. Tissue-speci c receptor (e. g. trh and trh receptor are found distributed throughout the central and peripheral nervous systems and in other tissues, such as thymus and small intestine epithelial cells) Ampli cation: one enzyme can activate more enzymes, each of which will also activate more enzymes; once signal transduction occurs, desensitization/adaptation often occurs. Desensitization/adaptation (e. g. smell, bright light to darkness, skin sensation) Integration: a cell responds as a whole by sensing all signals around them, integration them and responding. Termination: eventually, signal will eventually be terminated. Examples of signals that cells respond to: antigens, cell surface glycoproteins, developmental signals, growth factors, hormones, light, mechanical touch, neurotransmitters, nutrients. G protein-coupled receptor (gpcr): ligand binding activates an intracellular gtp-binding protein, which regulates an enzyme that generates an intracellular second messenger.

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