PHAR 300 Final: PHAR 300 - drugs

• School: McGill University
• Department: Pharmacology and Therapeutics
• Course: PHAR 300
• Professor: Edith Zorychta

Document Summary

* defective cyp2a6 lengthens half-life and also decreases carcinogenity of other compounds in cigs. * is a weak base and absorption depends on ph. * cigarettes are effective because the oral mucosa is a good environment and the lungs have a large surface area; also bypasses the liver. * alkaline urine causes nicotine to be non-ionised and reabsorbed. * highly lipid soluble and small rapidly absorbed into the blood. * absorption increased by carbonation/empty stomach, decreased by fats (rate of gastric emptying) * ethanol -> acetaldehyde by alcohol dehydrogenase; acetaldehyde -> acetate by acetaldehyde dehydrogenase. * antagonist and agonist at nachr leads to long-term inactivation. * stimulates and then blocks receptors in the ganglia. * stimulation of nachr (alpha4beta2) in vta leads to the involvement of dopamine reward. * presynaptic (alpha7) nachr enhance glutamate release also stimulates the dopaminergic cell. * non-alpha7 nachrs increase levels of gaba in the brain.