PHAR 300 Final: Toxicology
10 Jan 2019
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Document Summary
Insecticides: herbicides, food, forensic medicine, veterinary medicine, biological toxins (attack and defense, usually target nacchrs) Low doses can be used to treat certain heart diseases. Poisonous, will not be eaten (vs tulips which will be) A-moiety and b-moiety bound by disulfide bond. A-chain is an enzymatically-active toxin disrupts protein synthesis in cells. B-chain: binds to cell surface and allows for entry of a-chain. Food can be contaminated by bacteria, fungi, etc. Sources of exposure: everything we make is made of toxins. Heavy metals in electronics, for example : toxins are discarded into the environment, where they accumulate and concentrate up the food chain. Routes of exposure: respiration: air pollution does enter the blood stream, absorption: only if lipid-soluble. Ingestions: enters via gi tract: disability causes include: Electrical appliances : nox, so2, co2, co and mercury are found in, air pollution is harmful to lungs, heart and brain: Phagocytosed from lungs, but some pass into bloodstream.
