PHAR 301- Midterm Exam Guide - Comprehensive Notes for the exam ( 33 pages long!)
11 Oct 2017
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Document Summary
Phar 301 lecture 15: clarke (short notes) Moskowitz ma (1992) neurogenic vs vascular mechanisms of sumatriptan and ergot alkaloids in migraine. S diamond (2001) a fresh look at migraine therapy (no need to read about drug classes not mentioned in lecture) **drugs to know by name: caffeine, ergotamine, sumatriptan, triptans. Early migraine tx: trephination/trepanning drilling a hole in the skull to release evil spirits, ancient greeks inhaled smoke from burning coffee beans, ancient egyptians would use prayer and a clay crocodile placed on the patient"s head. What is a migraine: brain disease that involves several repeating episodes of ha, can be debilitating, associated with both structural and functional changes in the brain. Progression of an episode: prodrome warning signs seen in some pts. Sxs include: food cravings, fatigue, excitability, change of mood, yawning: aura seen in only 1/3 of sufferers. Sxs: blurred vision, flashing lights or zig-zag, missing area of the visual field (scotoma: ha and accompanying sxs, sleep.
