PSYC 318 Final: PSYC 318 Behavioural Neuroscience 2 Sossin lectures
8 Feb 2017
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Document Summary
Paper 6 the molecular biology of memory: camp, pka cre, creb-1, creb-2 and cpeb. Insertion/removal of membrane proteins, reversible but may require energy. Persistent activation of protein kinases, reversibility depends on mech of persistence. Production of new proteins, requires energy but persists based on the half-life of the protein or mrna. No pairing of stimuli (cs + us: no specific association between conditioned and unconditioned stimulus stimulus alone is strong enough to change behavior. Habituation is the decrease in a defensive reflex (cid:894) i(cid:374) se(cid:374)siti(cid:448)it(cid:455)(cid:895) due to repetitive non-noxious stimulation: uses the conditioned stimulus alone. Sensitization is the increase in a defensive reflex due to a noxious stimulus: uses the unconditioned stimulus alone, an example of this would be fear conditioning. Aplysia have both associative and non-associative memories. Reductionist (ask questions in the simplest system you can find) Neurons are large and identifiable between preparations (20 000 neurons in total: allows for tracing of the circuit underlying behavior.
