BIOLOGY 3UU3 Study Guide - Quiz Guide: Nadph Oxidase, Xanthine Oxidase, Cytochrome P450
7 Feb 2017
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Document Summary
Ros important physiological regulators of intracellular signaling pathways. Oxidation of specific and reactive cysteine residues lead to reversible medication of enzymatic activity. Regulates: response to growth factor stimulation, generation of the inflammatory response. Dysreguated ros can accelerate a host of pathological conditions including rate we age. Potential sources of ros within the cell: family of membrane-bound enzyme that rely on nadph for activity. Nadph-dependent oxidases have regulated generation of ros: mitochondria. Formed predominantly in complex i or iii of the cytochrome chain. Electrons initially derived from nadh or fadh2 react with oxygen to produce superoxide anions: other intracellular enzymes. Xanthine oxidase, cyclooxygenases, cytochrome p450 enzymes, lipoxygenases. Produce oxidants s part of their normal enzymatic function: mitochondria produced ros as part of aerobic respiration, phagocytic cells produce oxidants as part of a host defense mechanism. Production of hydrogen peroxide is essential for normal growth factor signaling: pdgf, and egf ligand binding burst of ros production.
