Kin 1Y03.docx

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Lovaye Kajiura

Lecture 3 Sept 13August12121128 PM EmbryologyWhere it all beganDuring fertilization 2 millions sperm are deposited into the vagina but only 1 make it through the cervix either immobile or cannot handle vaginal conditions etcSperm needs to use whiplike motion to make it through the cervix to the ampullasite of fertilizationAbout 200 sperm reach place of fertilizationEggsOocyteFallopian Tubes Uterine TubeOocyte is no longer viable after 24 hours because it only has nutrients to survive for 24 hours sperm has approx 48 hours Prenatal DevelopmentFrom conception to birth there are 3 stagesGerminal Period first 2 weeks of the development during formation of primitive 1germ layersEmbryonic Period weeks 38 of development organ systems develop2Fetal Period last 30 weeks organ system grow and mature3ClinicalMedical Events Date since last menstrual periodEmbryologists postovulatory age FertilizationMany sperm cells attach to corona radiata of secondary oocyteBinding of ZP3 species specificAcrosomal Reaction acrosome of sperm is an area containing genetic material the cap of the sperm that enters the oocyteCapacitationmaking sperm tail go faster because of female fluids making it capableBinding to a6b1 and depolarizationWhen one sperm cap enters an electric shock occurs preventing any other from enteringFast Block to Polyspermy depolarizationSlow Block to Polyspermyintercellular release of Caexocytosis of H2Ooocyte shrinkszona pellucida denaturesZona pellucida is a glyco protein found in the acrosome of sperm in humansVery species specific Female nucleus undergoes second meiotic division female pronucleusMale pronucleusFusion of haploid pronuclei produces zygote Even though cells divide the size stays the same until implantationMorula day 5Blastocyst day 6 packed cell stage to something with a cavity Blastomeres inside Morula at least 12Uteri milk gives nurtience and makes the cavity formLecture 4 Sept 14September1412823 AM Implantation and Formation of Placenta Implantation burrowing of the blastocyst into the uterine wallPlacenta exchange of nutrients and waste between mother and embryo allows the blood supply of mother and baby to connect but the blood cells never mix just come very close together to exchange suppliesSyncytiotrophoblast multinucleated cell invades the endometrium liquefy endometrium and cannot see a distinct cell wallsCytotrophoblast remains close to the embryonic tissue does have distinct cell wallsLacunae syncytiotrophoblast surround maternal blood vessels and digests their walls forming pools of blood1 Month cytotrophoblast provides a protective barrier between maternal and embryonic bloodMesoderm germ layer that creates blood vessels on embryotic sidebeginnings of the umbilical cordArteriole carries away from the heart and is blueVenule goes towards the heart that is redPluripotent stem cellcall make other things just not a full organismEmbryonic DiskAmniotic Cavity forms inside inner cell mass called the hypoblast and surrounded by a layer of cells the amnionForms After implantationembryonic disk composed of two layers epiblast and hypoblastEpiblast 3 germ layersHypoblast extraembryonic membranes Amniotic cavity eventually surrounds the developing embryo providing a protective fluid bag Yolk Sac forms inside blastocele from hypoblast Primitive StreakGroove in epiblastGoes from caudal tail end to cephalic head endEctoderm is topMesoderm in middleEndoderm on bottom Dizygotic twins 2 oocytes released and fertilized
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