ANSC 4470 Study Guide - Quiz Guide: Citric Acid Cycle, Sybr Green I, Cyclic Adenosine Monophosphate
5 Apr 2016
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Limited capacity for glucose oxidaion in fetal sheep with intrauterine growth restricion. (brown et al. Impact factor: number of citaions per year per paper (higher is beter) Interested in studying the intrauterine growth-restricted (iugr) fetus because it illustrates the prolonged efects of in utero situaions & shows fetal imprining efects. Glucose producion rate is not suppressed by insulin in the iugr fetus. Decreased glucose oxidaion results in increased lactate producion because if pyruvate accoa is inhibited, pyruvate lactate will occur: reduced glucose oxidaion increases lactate producion. In addiion to lactate, glycogen breakdown, amino acids & glycerol can be used for hepaic glucose producion. Iugr was induced by introducing hyperthermia to the ewes causing less blood low, less oxygen delivery & uptake. A balanced amino acid soluion was infused during the insulin clamp to ensure euaminoacidemic (keep the amino acid concentraions at basal levels) to study high insulin have to supplement the amino acids.
