BIOC 2580 Study Guide - Final Guide: Variable Number Tandem Repeat, Protease, Orf Eins
16 Dec 2015
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Document Summary
Risc picks the strand with the less stable end to unwind. It binds to both strands, but helicase unwinds the end that is easier to unwind first. As organisms get more complicated, there is an increase in mobile genetic elements. 50% of human genome is derived from mobile genetic elements. Cause of genetic variability by interrupting genes, influencing gene expression, shuffling exons and causing chromosome rearrangements. Transposon sequence encodes for transposase which is cut and excised to be integrated elsewhere. Moves through an rna intermediate and multiplies itself. Can cause disease if they jump into an exon of an important gene. Rnai can downregulate the mobility of these elements in the genome. One promoter (rna polymerase ii promoter) drives the transcription of l1 mrna while the other promoter drives transcription in the opposite direction producing two mrna transcripts complementary to each other from the l1 gene. Orf1: rna polymerase ii binding and chaperone activity.
