NUTR 4210 Study Guide - Final Guide: Adiponectin Receptor, Acute-Phase Protein, Adiponectin

• School: University of Guelph
• Department: Nutrition
• Course: NUTR 4210
• Professor: Lindsay Robinson

Document Summary

Cancer process: initiation: dna damage, irreversible cell changes, ros, hyperplasia primary tumor, promotion: evade immune system, promote tumor cell survival, angiogenesis, can take decades, progression: metastasis secondary tumor. More insulin and igf-1 (insulin-like growth factor) Increased estrogen: especially menopausal women and breast cancer, more estradiol, promotes angiogenesis of tumor. Adipocytes secrete less adiponectin and more leptin. Macrophages secrete tnf and il-6 (the inflammatory cytokines) Increases nfkb: transcription factor that increases tnf and il-6. Increases stat3: transcription factor that promotes cell proliferation and survival. Attracts neutrophils & immune cells into tumor environment to produce ros and cause dna damage, secrete more tnf and il-6. Promotes cancer cell proliferation, survival (block apoptosis), migration (metastasis) Mice lacking adiponectin show increased tumor number & size. Pro-apoptotic: activates caspases, stimulates cytochrome c release from mitochondria. Anti-inflammatory: stimulates ppar block nfkb activation and stimulates inflammatory cytokine production (tnf ) Binds to adiponectin receptor and activates appl1 anti-oxidant effects, reduce ros.