FNH 350 Study Guide - Final Guide: Phenylalanine Hydroxylase, Pancreatic Juice, Zymogen
30 Apr 2019
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Protein study guide: pro needed for life, make bodys own proteins, needed to carry out metabolic processes, repair, growth, maintenance of body. Structural: collagen, keratin, actin, myosin: enzymes: dehydrogenases, active in tca/glycolysis, hormones : cck, ghrelin, somatostatin, regulate metabolic processes, transporters: ceruplasmin (cu), transferrin (fe), albumin, transthyren, buffers: aa act as acid/base by release/accept h+ Immunoglobins/antibodies: produced by b-lymphocutes, antiviral/bacterial: carboxy/amino groups, regulations: fluid balance: attract h2o--> contributes to osmotic pressure. Fluid balance: other functions, acute phase reactant pro. Stimulate immune system to heal wounds, remove free fe(antibacterial: c reactant pro: clinical indicator for inflammation, storage: for cu, zn, fe (ferritin, conjugated proteins: glycoproteins. Single substitution of aa can disrupt substrate binding, configuration, folding-> function: methylene tetrahydrofolate reductase, a->v, decrease enzyme activity by 40%, decrease folate status, adverse effectives in pregnancy, alzheimers, autism. Liver function/cirrhosis: phenylalanine, methionine: phenylalanine, threonine, tyrosine, methionine, histidine, lysine, leucine, isoleucine, valine, preterm neonates: cysteine, proline, phenylketonuria(pku, no phenylalanine hydroxylase to turn phenylalanine->tyrosine.
