BIO 3124 Study Guide - Final Guide: Necrotizing Fasciitis, Transferrin, Impetigo
6 Feb 2015
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Lecture 18: bacterial virulence factors guest lecturer. Inactivated uv, heat, chemicals: attenuated weakened, mutations, deletions, conjugate polysaccharides linked to protein antigen. Bacterial virulence factors: molecules expressed and secreted by bacteria. Important for bacteria: allow entry/exit to cells, colonize a niche in host, inhibit host"s immune response, obtain nutrition from host, immunoevasion. Polysachharide capsules prevents phagocytosis/evasion of host immune system. Los causes septic shock, overwhelming immune system. Fimbriae mediates attachment of bacterium to epithelial cells: understanding pathogenesis, identification of targets for novel drugs, new vaccines, development of diagnostic tests, opa proteins bind to receptors on host cells, abc transporters. Pili used for attachment to host cells. Iron is essential for bacterial growth: enzyme cofactor synthesis of rna etc, used in reactive centres of enzymes, proliferation/virulence. Iron uptake mechanisms in bacteria: siderophores, solute specific receptor proteins, abc transporters. Neisseriae: gram negative bacteria, colonize on mucosal surfaces of animals. No current vaccine for serogroup b since capsular polysaccharide is similar to.
