CHM 2120 Study Guide - Hydrazone, Lithium Hydroxide, Meta-Chloroperoxybenzoic Acid
Document Summary
Answers: the aldol reaction can be accomplished using an acid catalyst. B = conjugate base of acid or solvent. Identify the cyclohexanone ring present in starting material (s. m. ) and product (p), then identify the new bond. The 1,3 relationship between the oxygens suggests that an aldol reaction would be appropriate. *a 1,3-relationship suggests that an aldol reaction would be appropriate. The required starting material, in blue, has been mapped on to the product (this could also be done by circling or numbering the atoms in starting material and product) Double bond made from elimination reaction, wittig. This route seems less direct than using an aldol reaction. 1,3 relationship allows for an aldol reaction--an excellent way to make new c-c bonds. Note that the ketone contains only 1 type of alpha proton and that the aldehyde does not possess -protons. It is therefore not necessary to make the enolate separately (although still acceptable).
