PHA 3112 Study Guide - Midterm Guide: Revascularization, Maladaptation, Thrombus

• School: University of Ottawa
• Department: Pharmacology
• Course: PHA 3112
• Professor: Pierre Fortier

Document Summary

Mimic 3 families of endogenous opioid peptides: enkephalins, endorphins, dynorphins. Used in withdrawl and maintenance as can"t be abused: antagonist: no response, blocks agonists (naloxone), nonopioid: relieve pain by unique mechanisms not opioid related. No resp depression, no dependence or abuse. (tramadol) Physical dependence/abuse/addiction: dependence rare with short term use. Gradual withdrawal necessary in the case of dependence. Addiction: chronic relapsing brain disease with compulsive drug seeking and use, despite harmful consequences. Tolerance: decreased response from same dose, increased dose needed. Cross tolerance: tolerance to drug a tolerance to drug b (for drugs in the same class) Physical dependence: withdrawal syndrome will develop if drug stopped abruptly. Cross dependence: drug b supports dependence on drug a but drug b prevents withdrawal if drug a is stopped. Drug abuse and alcohol: most common used/abused psychoactive substance in us/canada. Moderation can prolong life and decrease risk of dementia.