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University of Toronto Scarborough
Biological Sciences
Stephen Reid

Lecture 13 Study Notes Slide 2 While resting, we only utilie of oxygen in circulation o The other 75% is on reserve i.e. for when we exercise or increase metabolic demands Slide 3 (look at graph) Polycythaemia: overproduction of red blood cells o Greater than normal amount of haemoglobin then. Even though 100% saturation of Hb with O2 occurs, polycythaemia means total oxygen level is higher than normal Anaemia: reduction of red blood cells o Less than normal amount of haemoglobin Even though 100% saturation of Hb with O2 occurs, anaemia means total oxygen level is lower than normal Slide 4 Oxygen haemoglobin binding is modified by a variety of factors including temperature, pH, PCO2, and 2,3-DPG o Temperature and pH most important o These factors promote oxygen loading in the lungs and oxygen unloading in the tissues Remember loading was promoted in lungs due to high PO2 (100 torr), and unloading promoted in tissues due to low PO2 (40 torr) Slide 5 Factor 1: Temperature o Metabolically active tissuese higher temperatures. So Temperature
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