HMB265H1 Study Guide - Final Guide: Amine, Viral Vector, Xyy Syndrome

• School: UTSG
• Department: Human Biology
• Course: HMB265H1
• Professor: Maria Papaconstantinou

Document Summary

Qualities of a good model organism: short generation time, can be self-fertilized (inbred), simple reproductive biology, many progeny. Test crosses can be done with fully recessive individual to uncover traits of the target: this will reveal any recessive alleles that are hidden, monohybrid (3:1) or dihybrid (9:3:3:1) will work with this method. Sum rule: calculates the probability that a or b will occur mutually exclusive events: add each of the probabilities together, as shown below left. Product rule: calculates the probability that a and b will occur independent events: multiply each of the individual probabilities together, as shown below right. Lecture 3: molecular basis of genetic polymorphisms and. Mutant = allele whose freq < 1% Monomorphic: gene with only one wt; polymorphic: gene with > 1 wt. Lecture 4: mendelian traits in humans and pedigree analysis. Autosomal inheritance: affects non-sex chromosomes so everyone has same chance of getting.