Study notes for exam

2 Pages
137 Views
Unlock Document

Department
Molecular Genetics and Microbiology
Course
MGY377H1
Professor
William Navarre
Semester
Fall

Description
33 What do SPI2 effectors do to host cellsMacrophage cell deathslow Global inhibition of endosome maturation Alter signal transductiono Decreased IL9 productionpro inflammatoryo Increased IL10 productionmacrophage deactivation Block delivery with NADPH oxidase and iNOS o Prevents exposure of bacteria to reactive oxygen and nitrogen intermediates Modulate actin dynamics at the Salmonellacontaining vacuole Cholesterol accumulation at the Salmonellacontaining vacuole Sif formationstability of SCVSalmonellainduced filaments Function unclear Epitheial cells and macrophages in vitro Result from fusion of late endocytic compartments with SCVRequire at least four effectors for formationstabilityo SifA o SseF SseG Encoded with SPI2No catalytic function identified Localized to SCV and SifsMutants deficient in Sif formation Recruits host dynein a microtubule motor complex May play role in acquiring nutr
More Less

Related notes for MGY377H1

Log In


OR

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


OR

By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.


Submit