PSL300H1 Study Guide - Final Guide: Circumventricular Organs, Anterograde Amnesia, Choroid Plexus

• School: UTSG
• Department: Physiology
• Course: PSL300H1
• Professor: Dr.Buchan, Dr.Kee, Dr.Tweed

Document Summary

Adult neurogenesis: historical background, neurogenesis and learning, regulation of adult neurogenesis. The brain and the spinal cord are protected from the general circulation and the body. The ionic composition of the ecf around the neuron must be carefully controlled: cannot change the excitability of the membrane. E. g. , kcl injection decreased k+ concentration gradient depolarization inactivation of na+ channel no ap produced: cannot have neurotransmitters floating around for no reason. Thus, the ecf in the neuronal environment (brain and spinal cord) are carefully regulated through bbb. There is a lot of things floating around in general circulation; e. g. , injecting kcl affects concentration gradient and the membrane remains depolarized. The fluid bathing the neurons has to be (cid:272)arefull(cid:455) (cid:373)oderated a(cid:374)d (cid:272)o(cid:374)trolled. We also (cid:272)a(cid:374)(cid:859)t ha(cid:448)e nts floating around everywhere, if it reaches synapses it will mess up the whole signaling system. Fluid bathing neurons is regulated, possible due to the bbb. The brain and spinal cord is isolated from the general circulation.