Biochemistry 2280A Study Guide - Midterm Guide: Serine Protease, Hemoglobin, Competitive Inhibition
14 Dec 2017
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Dna = genotype; rna/ protein = phenotype. Topic 2 - amino acids & peptide bonds. The carbon is a sterocentre, both l & d exist with 50-50 ratio, but only l-forms are used in proteins (evolutionary selection) Non polar, uncharged side chains can be: Glycine: r-group is just an h atom. Proline: made of imino group (nh2), and forms a loop. Basic: - ve charged. (both have coo- as r group) Acidic: +"ve charged (have nh3+ as part of r group) Polar uncharged (net charge 0, but charges are not evenly distributed) Majority of aa"s are uncharged (either uncharged polar, or uncharged non-polar) Phosphorylation happens on aa"s with oh group (ser, thr, tyr) Ionization of aa changes as h+ [ ] changes, since this a ects the association/ dissociation of protons. Aa"s are amphoteric (contains both acidic & basic groups), & may exist as zwitterions (carry both + & - ve charges)
