Biology 2581B Study Guide - Quiz Guide: Start Codon, Wild Type, Guanine

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Disorders caused by dominant alleles, only requiring one copy of the allele or the phenotype to be expressed can often be lethal when in the homozygous form. A single copy of the wild-type allele is not always sufficient for normal functioning or even survival. The dominant lethal inheritance pattern is one in which an allele is lethal both in the homozygote and the heterozygote; this allele can only be transmitted if the lethality phenotype occurs after reproductive age. Individuals with mutations that result in dominant lethal alleles fail to survive even in the heterozygote form. Dominant lethal alleles are very rare because, as you might expect, the allele only lasts one generation and is not transmitted. However, as with recessive lethal alleles the phenotype of death may not be expressed immediate. Common with heterozygotes, those with only one dominant copy, they may survive birth and reach adulthood before expression of the lethal allele.

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