Biology 2581B Study Guide - Quiz Guide: Missense Mutation, Stem-Loop, Synthetic Lethality
3 Jun 2020
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The suppressor would cause a second change to improve the substrate binding affinity: there is a mutation in the second gene that counteracts the mutation in the first gene (intergenic suppression) Rna itself: the stem loop will be bound by specific rna binding sequences that recognise either the stem or loop. Partial loss of kinase or phosphatase function both alter the equilibrium in different directions. The equilibrium is restored in double mutant individuals. Here, when the kinase is suppressed, the wee 1 mutant cells advance into the active. Any second site dna variation in the strain that modifies the phenotype of the mutation, especially one that suppresses, will be selected for and can become fixed. Epistasis: the normal activity of a series of enzymes that make a product. If enzyme b is not suppressed, no product is made and intermediate 1 builds up. Cells with a single mutated gene will still function normally.
