Microbiology and Immunology 2500A/B Study Guide - Midterm Guide: Immunoglobulin M, Antigen Presentation, Follicular B Helper T Cells
10 Sep 2020
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Microimm 2500a - fall 2018 | 12 of 21 3. 0 adaptive immunity lecture: 5 | date: sep 17 instructor: dr. kelly summers learning objectives 1. define the terms: antigen , epitope , clonal expansion . 2. describe the kinetics of a primary vs. memory immune response . 3. state the primary lymphoid tissues important in b vs. t cell development. 4. state the importance of each type of secondary lymphoid tissue in adaptive immunity. 5. define the structure of b and t cell receptors . Primary immune response refers to first exposure to pathogen. 1. establishment of infection: innate response, if [pathogen] exceed threshold, proceed to (2). 2. induction of adaptive response: naive bc/tc effector cells 3. adaptive immune response 4. memory: effector memory cells memory immune response refers to subsequent exposure to identical pathogen. Memory cells for antibodies have a 75 year lifespan while memory t-cells have a 40 year lifespan . Clinical case smallpox (variola virus) shows no significant decrease in ab concentration decades post-vaccinations.
