Pharmacology 2060A/B Study Guide - Final Guide: Hypotension, Lipophilicity, Bioavailability
4 Jan 2017
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Document Summary
Is defined the study of drug movement in the body. Is what the body does to the drug. x pharmacokinetics is composed of four basic processes: Over time dissolution occurs and the drug molecules are dissolved in the liquid. Pharmaceutical phase x the pharmaceutical phase occurs after the patient swallows a tablet. x x. It involves the disintegration of the tablet and the dissolution of the drug. If the drug does not completely disintegrate or does not go into solution, absorption is reduced. Enteric coating x drugs with enteric coating are covered with a special coating that prevents their dissolution in the acidic environment of the stomach. x once the drug passes into the more alkaline duodenum, the enteric coating dissolves. Bioavailability x bioavailability is the fraction of a dose of drug that reaches the systemic circulation unchanged. x bioavailability can be influenced by: drug formulation, route of administration, degree of metabolism, sublingual x.
