ENVS 1000 Study Guide - Final Guide: Genotype Frequency, Genetic Drift, Population Genetics

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New definition of evolution : a change in the allele and/or genotype frequencies of a population. Collectively, allele and genotype frequencies make up the genetic structure of a population. Evolution is therefore a change in the genetic structure of a population. A population whose allele and genotype frequencies are constant from one generation to the next, is not evolving (i. e. it is in h-w equilibrium h-w equation will predict genotype frequencies. The population is not evolving, i. e. it is in hardy-weinberg equilibrium (aka genetic equilibrium) H-w equation will give the genotype frequencies of the current, next, and any subsequent, generation. Natural selection: hardy-weinberg equation assumes all individuals survive and reproduce equally well, but natural selection eliminates individuals with genotypes that are unfit for a given environment --> changes allele and genotype frequencies. Recessive disorders in humans: many genetic disorders e. g. sickle-cell anemia, tay-sachs disease, cystic fibrosis, phenylketonuria (pku), and others behave as simple mendelian traits associated with a recessive allele.

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