KINE 4450 Study Guide - Final Guide: Vastus Lateralis Muscle, Knockout Mouse, Vascular Endothelial Growth Factor
17 Apr 2017
School
Department
Course
Professor
Document Summary
Several hypotheses: metabolic hypothesis: local tissue/cellular hypoxia. Seems to be the most important: hemodynamic hypothesis: shear stress - blood flow, pressure, activates endothelials, mechanical hypothesis: tissue/cellular stretch - release proteases, activates endothelials. Vegf mrna, acute exercise and altitude: just altitude (hypoxia) had vegf; altitude and exercise had vegf 0 and 2 hours after. Hypoxia may boost exercise effects: had significant increase in bfgf after exercise which makes sense, but exercise and altitude had no change in levels, no effect of hypoxia, confusing results, tgf levels followed same pattern as vegf. Exercise and transcription/growth factors: knee extensors exercise, vastus lateralis sample, no difference in vegf, fgf, hif-1 / in restricted blood flow or non-restricted conditions. Effects of passive or contraction hyper-perfusion: dog skeletal muscle, looked at angiogenic growth factor mrna responses, more blood volume, friction and pressure, flow from exercise (contraction) had significantly more vegf, no change in bfgf.
