NATS 1670 Study Guide - Final Guide: Reverse Transcriptase, Nevirapine, Lamivudine

• School: York University
• Department: Natural Science
• Course: NATS 1670
• Professor: Motti Anafi

Document Summary

Enzyme: a protein (some sort of structure which allows changes to other molecules) Substrates need to fit the enzyme-binding site (active site) Competitive inhibitors: small parts of the substrate not enough to activate the enzymatic activity, and also prevents the real substrate from successfully fitting the active site, think of a lock (enzyme) and key (substrate) If a competitive inhibitor is inside of the lock, no enzymatic activity can take place, because the substrate could not fit in the enzyme anymore: enzyme + competitive inhibitor + substrate = no enzymatic activity. Azt: a competitive inhibitor for hiv replication: phosphodiester bond (look back at notes): the phosphates connecting to a hydroxyl on another nucleotide, first drug created against hiv, thymidine (t) and azt are almost identical, except: Instead of the hydroxyl (waiting to be connected to another nucleotide), there is. Nucleotide-like competitive rt inhibitors: taking away the hydroxyl from nucleotides and trying to use other sources (like.