NATS 1770 Study Guide - Denisova Cave, Cloning, 1918 Flu Pandemic
Document Summary
An international project to study the entire genetic material (genome) of the human funded by countries around the world. Aim : to better understand our genome mapping , better understand disease, compare genomes, 2. introns, regulatory elements: pseudogenes multiple copies of genes. 6. intergenic sequences aka junk dna, dark mater no known function intergenic sequences repeats cpg islands upstream of the huntington gene for instance. Biggest aim: to better understand disease, to better understand and to analyse the difference between wildtype genotypes and mutated ones, The human genome project made use of genome wide associations: most mutations are in the non-coding regions esp in the intronic and intergenic regions. That being said, exome sequencing was not useful and the project did not make great use of it. The human genome project has allowed the world of genetics to understand the differences between humans and all other organisms: genome size and complexity do not correlate.
